溶于水、乙醇、丙酮、苯、甲苯、二甲苯、二氯乙烷、氯仿、乙酸、乙酐、乙酸乙酯、已烷、四氢呋喃、三乙胺、吡啶、DMF 等溶剂，水中溶解度:76 g/l (25°C)。酰化反应的高效催化剂 4-二甲氨基吡啶（DMAP）是一种多功能亲核催化剂，用于酰化和酯化反应。它也可用于各种有机转化反应，如Baylis-Hillman反应、Dakin-West反应、胺的保护、C-酰化、硅烷化、天然产物化学中的应用。 应用 4-二甲氨基吡啶可用作以下反应的催化剂： 通过与丙二腈、醛和β-硝基烯反应合成3,5 取代的2,6-二氰基苯胺。 在无辅助碱和溶剂的条件下与酸酐进行醇的酰化反应合成相应的酯。 通过活化烯和醛或酮的偶联进行Baylis-Hillman 反应生成碳碳键。 酰化反应的高效催化剂。 A highly efficient catalyst for acylation reactions 4-Dimethylaminopyridine (DMAP) is a versatile nucleophilic catalyst used in acylation and esterification reactions. It can also be used in various organic transformations such as Baylis-Hillman reaction, Dakin-West reaction, protection of amines, C-acylation, silylation, and applications in natural product chemistry. Application 4-Dimethylaminopyridine can be used as a catalyst for the following reactions: Synthesis of 3,5-substituted 2,6-dicyanoanilines by reaction with malononitrile, aldehydes and β-nitroolefins. Acylation of alcohols with anhydrides to synthesize the corresponding esters in the absence of auxiliary bases and solvents. Baylis-Hillman reaction to generate carbon-carbon bonds by coupling of activated alkenes with aldehydes or ketones. Efficient catalyst for acylation reactions.
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4-Dimethylaminopyridine
Dangerous GoodsCAS number：1122-58-3 molecular formula：C7H10N2
overview
compound introduction
Specs
| Chinese alias | N-(4-吡啶基)二甲基胺 | N,N-二甲基-4-吡啶胺 | 4-（二甲氨基）吡啶 | ||
| English alias | N,N-dimethyl 4-pyridinamine | p-dimethylamino pyridine | (4-DMAP);4-Dimethylaminopyridine | 4-di methylaminopyridine | 4-Dimethylaminepyridine | N,N-dimethyl-N-(4-pyridinyl)amine | dimethyl-pyridin-4-yl-amine | dimethyl-pyridin-4yl-amine | dimethylpyridin | ||
| CAS number | 1122-58-3 | molecular formula | C7H10N2 |
| molecular weight | 122.17 g/mol | Exact mass | ≥99% |
| PSA | 16.100 Ų | logp | 1.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS08 , GHS09 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H331: 吸入会中毒 H411: 对水生生物有毒并具有长期持续影响 H314: 造成严重的皮肤灼伤和眼睛损伤 H318: 造成严重的眼睛损伤 H310: 与皮肤接触致命 H370: 对器官造成损害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
WGK Germany：
3
Personal protective equipment：
Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS：
US9230000
UN Number：
2811
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
1122-58-3 | 4-(Dimethylamino)pyridine.pdf
