4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen.It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen.It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.
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4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
Dangerous GoodsCAS number：17129-06-5 molecular formula：C2H5OCH=CHCOCF3
overview
compound introduction
Specs
| Chinese alias | (E)-4-乙氧基-1,1,1-三氟-3-丁烯-2-酮 | ||
| English alias | BBL104347 | ETFBO | (3Z)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one | 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one, contains 0.5% BHT as stabilizer, technical grade | Foscarb | 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one | (e)-4-ethoxy-1,1,1-trifluoro-3-buten-2-one (sta | ||
| CAS number | 17129-06-5 | molecular formula | C2H5OCH=CHCOCF3 |
| molecular weight | 168.11 g/mol | Exact mass | ≥94% |
| PSA | 26.300 Ų | logp | 1.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS02
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H314: 造成严重的皮肤灼伤和眼睛损伤 H412: 对水生生物有害并具有长期持续影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H226: 易燃液体和蒸气 H330: 吸入致命 H372: 通过长时间或反复暴露对器官造成损害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405:
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
17129-06-5 | 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one.pdf
