Amiloride HCl dihydrate

Dangerous Goods

CAS number：17440-83-4 molecular formula：C6H8ClN7O·HCl·2H2O

overview

Specs

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physicochemical properties

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Production methods and uses

MSDS

overview

compound introduction

Amiloride HCl dihydrate是一种有效的上皮细胞钠离子通道抑制剂。An epithelial sodium channel blocker Information Amiloride HCl dihydrate Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure. In vitro Amiloride also induces the dephosphorylation of P13K (phosphatidylinositol 3-kinase) and PDK-1 (phosphoinositide-dependent kinase-1) kinases along with PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PP1 alpha phosphatases. Amiloride inhibits phosphorylation of kinases and phosphatases by competing with ATP. Amiloride, which causes little or no cytotoxicity by itself, enhances TRAIL-induced apoptosis. Amiloride precludes the alkalinization and in parallel inhibit cellular proliferation. Amiloride directly inhibits autophosphorylation of the EGF receptor. Amiloride significantly enhances recovery to a maximum of 39%, 88%, and 78% for force, +dF/dt, and -dF/dt, respectively. Amiloride, a frequently used inhibitor of Na+/H+ exchange, rapidly inhibits phorbol ester-stimulated protein phosphorylation in vivo and protein kinase C-mediated phosphorylation in vitro, both with potency similar to that with which Amiloride inhibits Na+/H+ exchange. Amiloride blocks phorbol ester-induced adhesion of HL-60 cells (adhesion being a property indicative of the differentiated state), but dimethylamiloride (as well as ethylisopropylamiloride, another very potent amiloride analog) does not. Amiloride inhibits the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥100%

Specs

Chinese alias	盐酸阿米洛利二水合物
English alias	Amilorid hydrochlorid-2-wasser \| UNII-FZJ37245UC \| AMILORIDE HYDROCHLORIDE [EP IMPURITY] \| J-010987 \| Q27105756 \| Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride dihydrate \| DTXSID80169826 \| NSC-755847 \| HMS1568A15 \| 3,5
CAS number	17440-83-4	molecular formula	C6H8ClN7O·HCl·2H2O
molecular weight	302.12 g/mol	Exact mass	10mM in Water
PSA	161.000 Å²	logp	-

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Safety information

pictogram：

GHS06 , GHS07

Signal word：

Danger

Hazard Statement：

H319: 引起严重眼睛刺激 H412: 对水生生物有害并具有长期持续影响 H300: 吞咽致命

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果