链脲佐菌素是一种氨基葡萄糖-亚硝基脲(glucosamine-nitrosourea)，是一种DNA烷基化试剂，能通过GLUT2葡萄糖转运蛋白（GLUT2 glucose transport protein）独自进入细胞。对胰腺胰岛内胰岛素诱发的β-细胞具毒性。链脲佐菌素对GLUT2 阳性神经内分泌肿瘤细胞有毒性作用。 Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells. An NO donor and DNA methylating agent; Streptozotocin is used in medicine as a drug against certain cancers of the Langerhans Islets. It is cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter; Streptozocin is used to induce Type 1 diabetes for medical research.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Streptozocin
Dangerous GoodsCAS number：18883-66-4 molecular formula：C8H15N3O7
overview
compound introduction
Specs
| Chinese alias | 链脲菌素 | ||
| English alias | N-(Methylnitrosocarbamoyl)-α-D-glucosamine | Streptozotocin | 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose | STZ | NSC-85998 | U-9889 | ||
| CAS number | 18883-66-4 | molecular formula | C8H15N3O7 |
| molecular weight | 265.22 g/mol | Exact mass | - |
| PSA | 152.000 Ų | logp | -1.400 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08
Signal word：
Danger
Hazard Statement：
H350: 可能导致癌症
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
WGK Germany：
3
Personal protective equipment：
Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS：
LZ5775000
UN Number：
3077
Packing Group：
III
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
18883-66-4 | Streptozotocin.pdf
