Pomalidomide抑制LPS诱导的TNF-alpha释放， IC50为13 nM。 应用： 泊马度胺已被用于：处理BV173 细胞以研究蛋白质水解靶向嵌合体 (PROTAC) 化合物 JQ1-CRBN 在诱导特异性 I 类主要组织相容性复合体 (MHC-I) 肽中的作用 ；用于细胞凋亡研究和细胞内钙分析；作为胎儿血红蛋白 (HbF) 试剂用于研究 对& #946;-地中海贫血/变异血红蛋白 E (HbE) 红系祖细胞中胎儿血红蛋白表达水平与UNC0638 的累加效应。 Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease. Application： Pomalidomide has been used:to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides；for apoptosis studies and intracellular calcium analysis；as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells.
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Pomalidomide
Dangerous GoodsCAS number：19171-19-8 molecular formula：C13H11N3O4
overview
compound introduction
Specs
| Chinese alias | 泊马度胺 | TNF-alpha抑制剂 | 3-氨基-N-(2,6-二氧-3-哌啶基)苯邻二甲酰亚胺 | 3-氨基-N-（2,6-二氧代-3-哌啶基）苯甲酰胺 | 1,3-二氧代-2-（2,6-二氧哌啶-3-基）-4-氨基异吲哚 | 4-氨基-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮 | ||
| English alias | Pomalidomide (CC-4047) | POMALIDOMIDE [EMA EPAR] | POMALIDOMIDE [WHO-DD] | SCHEMBL369172 | BCP02890 | DTXCID801323473 | Pomalyst | IMID-3 | 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | LACTONE | SR-01000941573 | AC-26970 | MLS006011261 | AKOS0 | ||
| CAS number | 19171-19-8 | molecular formula | C13H11N3O4 |
| molecular weight | 273.24 g/mol | Exact mass | - |
| PSA | 110.000 Ų | logp | 0.2 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Danger
Hazard Statement：
H373: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H360Df: 可能会伤害未出生的孩子； 怀疑破坏生育力 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany：
2
Production methods and uses
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downstream information
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MSDS
Found 1 shareMSDS
19171-19-8 | Pomalidomide.pdf
