Brefeldin A可溶于DMSO(20mg/ml)，乙醇(5mg/ml)和甲醇(10mg/ml)。 使用说明： 1. Brefeldin A常见使用浓度范围为1-50μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细 胞和组织，通过实验进行摸索和优化。Brefeldin A，是一种常用的蛋白转运抑制剂，特异性地可逆地阻断蛋白质从内质网(ER)转运到高尔基体 (Golgi)。Brefeldin A处理后，高尔基体会很快被破坏，并融合到内质网上，该过程呈现能量、温度和微管依赖性。在哺乳动物和酵母中，Brefeldin A对蛋白从内质网向高尔基体转运的抑制可能是通过一类可以激活Afr1p GTPase的GTP-exchange factors来实现的。Arf1p在通过招募coat proteins到细胞内膜形成转运小泡(transport vesicles)的过程中起重要作用。Brefeldin A是一种真菌代谢产物，最初曾被用作抗病毒试剂，现在主要用于研究蛋白转运。Brefeldin A也常被用于抑制细胞因子等蛋白的分泌，并用于增强分泌蛋白的免疫染色检测。Brefeldin A 可激活神经鞘磷脂循环(sphingomyelin cycle)，还可诱导一些肿瘤细胞发生凋亡。 Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at
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Brefeldin A
Dangerous GoodsCAS number：20350-15-6 molecular formula：C16H24O4
overview
compound introduction
Specs
| Chinese alias | 蛋白转运抑制剂 | 烟碱 | γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯 | γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烷巴豆酸-λ-内酯 | 壳二孢毒素 | 蓝菌素 | 斜卧菌素 | ||
| English alias | BFA | BFA | MLS002701937 | s7046 | Decumbin | 4H-Cyclopent(f)oxacyclotridecin-4-one, 1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl- | brefeldin A | SMR000653527 | AM84700 | cid_5287620 | SMR000768725 | NSC-89671 | | ||
| CAS number | 20350-15-6 | molecular formula | C16H24O4 |
| molecular weight | 280.36 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 66.800 Ų | logp | 2.000 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P301+P310: 如误吞咽：立即呼叫急救中心/医生。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US),Eyeshields,Faceshields,Gloves
RTECS：
GY8410000
UN Number：
2811
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
20350-15-6 | Brefeldin A Solution | Brefeldin A
