奥卡西平(oxc)是卡马西平的酮类似物。与卡马西平不同，奥卡西平没有副作用。它是一种抗癫痫药物，具有抗神经痛的特性。它比卡马西平具有药代动力学优势。它用于治疗神经性疼痛，并作为三叉神经痛的有效止痛药。OXC向其单羟基衍生物的分解代谢具有显著的药理特性。它调节钾通道和电压依赖性钠通道。oxc调节集合管中的v2受体-g蛋白复合物。 奥卡西平已被用于人类癫痫性脑内皮细胞的反相高效液相色谱分析中。 Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia.The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus. Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.
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Oxcarbazepine
Dangerous GoodsCAS number：28721-07-5 molecular formula：C15H12N2O2
overview
compound introduction
Specs
| Chinese alias | 10,11-二氢-10-氧代-5H-二苯并[b,f]氮杂-5-甲酰胺, 奥卡西平 | ||
| English alias | OXCARBAZEPINE (USP-RS) | Oxcarbazepinum | DTXSID0045703 | OCBZ | OXCARBAZEPINE [MART.] | Oxcarbazepine [USAN:USP:INN:BAN] | UNII-VZI5B1W380 | EINECS 249-188-8 | HMS2090F13 | MFCD00865307 | MLS000084586 | OXCARBAZEPINE [USAN] | Spectrum2_000483 | 10,11-Dih | ||
| CAS number | 28721-07-5 | molecular formula | C15H12N2O2 |
| molecular weight | 252.27 g/mol | Exact mass | - |
| PSA | 63.400 Ų | logp | 1.7 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
HN8445000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
28721-07-5 | Oxcarbazepine (100 mg).pdf
