对甲苯磺酰甲基异腈在微波辐射下与固定化亚胺进行碱促进的1,3-偶极环加成反应，得到1,5-二取代咪唑。它是有机化学中的多功能合成子，广泛用于杂环化合物的合成。 用途 对甲基苯磺酰甲基异腈： 用于具有1,3,5-三氧杂环己烷骨架的三联体药物的合成中 用作制备生物活性吡咯和咪唑的试剂 用作使用糖衍生醛的非对映选择性雀形目反应中的异腈组分 Product Introduction p-Toluenesulfonylmethyl isocyanide undergoes base-promoted 1,3-dipolar cycloaddition reaction with immobilized imines under microwave irradiation to yield 1,5-disubstituted imidazoles. It is a versatile synthon in organic chemistry, extensively used for the synthesis of heterocyclic compounds. Application p-Toluenesulfonylmethyl isocyanide was used: in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton as reagent in the preparation of biologically active pyrroles and imidazoles as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes
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p-Toluenesulfonylmethyl isocyanide
Dangerous GoodsCAS number：36635-61-7 molecular formula：CH3C6H4SO2CH2NC
overview
compound introduction
Specs
| Chinese alias | 对甲苯磺酰甲基异腈 | 对甲基苯磺酰甲基异腈 | 4-甲基苯磺酰甲基异腈 | N-对甲苯磺酰甘氨 | ||
| English alias | (4-METHYLPHENYLSULFONYL)METHYL ISOCYANIDE | p-toluensulfonylmethyl isocyanide | UNII-C35FD6OLH8 | (p-toluenesulfonyl)methylisocyanide | 1-(isocyano methylsulfonyl)-4-methylbenzene | MFCD00000005 | DL-trans-Chrysanthemummonocarboxylic acid | Isocyanomethyl | ||
| CAS number | 36635-61-7 | molecular formula | CH3C6H4SO2CH2NC |
| molecular weight | 195.24 g/mol | Exact mass | ≥98% |
| PSA | 46.900 Ų | logp | 1.3 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 H301+H311+H331: 吞咽、皮肤接触或吸入中毒。
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良
WGK Germany：
3
Personal protective equipment：
Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
UN Number：
2811
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
36635-61-7 | p-Toluenesulfonylmethyl isocyanide.pdf
