氟前列腺素是一种PGF |2α| R（前列腺素F（FP）受体）激动剂，比PGF |2α|更具选择性。该化合物可以激活大鼠主动脉中ERK 2（细胞外信号调节激酶（ERK）），p38-丝裂原活化蛋白激酶（MAPK）和JNK | 3 |（c-Jun N端激酶（JNK））的磷酸化。研究表明，它可以通过抑制内皮素（ET）-1依赖性而改善通过小梁网（TM）的房水流出，从而诱导人肌细胞中的磷脂酶C和Ca | + |动员，并降低眼内压（IOP）。机制。氟前列腺素还抑制3T3-L1细胞中成脂基因的表达。 Fluprostenol is a PGF|2α|R (prostaglandin F (FP) receptor) agonist that is more selective than PGF|2α|. The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK|3|(c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca|+|mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.
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Fluprostenol
Dangerous GoodsCAS number：40666-16-8 molecular formula：C23H29F3O6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid | rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept- | ||
| CAS number | 40666-16-8 | molecular formula | C23H29F3O6 |
| molecular weight | 458.47 g/mol | Exact mass | - |
| PSA | 107.000 Ų | logp | 2.900 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS07
Signal word：
Danger
Hazard Statement：
H302: 吞食有害 H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命 H372: 通过长时间或反复暴露对器官造成损害 H370: 对器官造成损害 H300+H310+H330: 吞咽，皮肤接触或吸入会致命。
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持
WGK Germany：
1
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