Lonidamine

Dangerous Goods

CAS number：50264-69-2 molecular formula：C15H10Cl2N2O2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

氯尼达明已用作：糖酵解抑制剂，以研究其对肿瘤干细胞（CSC）中上皮间质转化（EMT）的影响线粒体通透性转换（MPT）诱导药物，研究其对替莫唑胺耐药的恶性胶质瘤细胞株的影响线粒体己糖激酶抑制剂，以测定人急性髓系白血病细胞中的活性氧（ROS） Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro. It elicits cell apoptosis and blocks CFTR Cl- channel.

Specs

Chinese alias	-
English alias	AF-1890;Diclondazolic Acid;DICA \| AM20060642 \| CCG-204803 \| A929099 \| KN-228 \| Lopac-L-4900 \| Diclondazolic acid \| HMS3412P05 \| L 4900 \| NCGC00015609-09 \| Pharmakon1600-01503225 \| WDRYRZXSPDWGEB-UHFFFAOYSA-N \| 1-(2,4-dichlorobenzyl)indazole-3-carboxylic a
CAS number	50264-69-2	molecular formula	C15H10Cl2N2O2
molecular weight	321.16 g/mol	Exact mass	-
PSA	55.100 Å²	logp	4.300

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS07

Signal word：

Danger

Hazard Statement：

H351: 怀疑引起遗传缺陷 H302: 吞食有害 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。

WGK Germany：