Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. In Vitro Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID 50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:mAChR
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Cimetropium Bromide
Dangerous GoodsCAS number：51598-60-8 molecular formula：C21H28BrNO4
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Specs
| Chinese alias | 西托溴铵 | ||
| English alias | 0C7M5WE60Q | 3-Oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane, 9-(cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))- | CIMETROPIUM BROMIDE [JAN] | SCHEMBL26842 | 8-(Cyclopropylmethyl)-6beta,7beta | ||
| CAS number | 51598-60-8 | molecular formula | C21H28BrNO4 |
| molecular weight | 438.36 g/mol | Exact mass | ≥96% |
| PSA | 59.100 Ų | logp | - |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
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