应用： 吡非尼酮用于： 1、作为兔的术后滴眼剂，分析其抗纤维化作用，改进青光眼滤过手术。 2、作为抗瘢痕形成剂，检查其是否影响兔植入青光眼引流装置（GDD）后的异物反应。 3、在人眼眶成纤维细胞（hOF）原代培养物中测试其抗纤维化潜力。 4、作为肿瘤坏死因子（TNFα）抑制剂，研究其在缺氧中的作用。 说明： 吡非尼酮（5-甲基-1-苯基-2-[1H]-吡啶酮）是合成的吡啶衍生物。 Application： Pyrfenidone is used for: 1、 As a postoperative eye drop for rabbits, analyze its anti fibrotic effect and improve glaucoma filtration surgery. 2、As an anti scarring agent, check if it affects the foreign body reaction after implantation of glaucoma drainage device (GDD) in rabbits. 3、Test its anti fibrotic potential in primary culture of human orbital fibroblasts (hOF). 4、 As tumor necrosis factor (TNF) α） Inhibitors, studying their role in hypoxia. Explanation： Pyrfenidone (5-methyl-1-phenyl-2- [1H] - pyridone) is a synthesized pyridine derivative.
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Pirfenidone
Dangerous GoodsCAS number：53179-13-8 molecular formula：C12H11NO
overview
compound introduction
Specs
| Chinese alias | 吡非尼酮 | 5-甲基-1-苯基-2-(1H)-吡啶酮 | ||
| English alias | MFCD00866047 | Pirfenidona [INN-Spanish] | PIRFENIDONE [INN] | Pirfenidone(AMR69) | 5-Methyl-1-phenyl-2(1H)-pyridone | ESBRIET COMPONENT PIRFENIDONE | LP00907 | NCGC00024992-02 | 1-phenyl-5-methyl-2-pyridinone | DTXSID4045183 | NCGC00015806-05 | HMS3262F1 | ||
| CAS number | 53179-13-8 | molecular formula | C12H11NO |
| molecular weight | 185.22 g/mol | Exact mass | - |
| PSA | 20.300 Ų | logp | 1.9 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US)， Eyeshields， Gloves
RTECS：
UV1148200
Production methods and uses
No production method and use information yet
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upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
53179-13-8 | Pirfenidone.pdf
