DNA拓扑异构酶II(topoisomerase II) 抑制剂。 Product Describtion: Amsacrine hydrochloride is a DNA topoisomerase II inhibitor. Product Application： Amsacrine: A DNA Intercalator with the Inhibition of Topoisomerase IIAmsacrine (known as m-AMSA) hydrochloride is an acridine derivative that has a potent antitumor activity against leukemic cells. Amsacrine inhibits topoisomerase II which is a group of essential enzymes for DNA replication with important functions for DNA function and cell survival. Topoisomerase II is now viewed as an important cellular target of antitumor drugs including both DNA intercalators (amsacrine and doxorubicin [D4193]) and the nonintercalator epipodophyllotoxin derivatives (etoposide [E0675] and teniposide [T3109]). Amsacrine is often used in combination with other chemotherapy drugs to treat types of adult leukemia, particularly acute myeloid leukemia (AML). (The product is for research purpose only.)
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Amsacrine hydrochloride
Dangerous GoodsCAS number：54301-15-4 molecular formula：C21H19N3O3S·HCl
overview
compound introduction
Specs
| Chinese alias | 安吖啶,胺苯吖啶 | ||
| English alias | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride | s5627 | Tox21_111212 | 4'-(9-Acridinylamino)methanesulfon-m-aniside monohydrochloride | NCGC00260839-01 | METHANESULFONAMIDE, N-(4-(9-ACRIDINYLAMINO)-3-METHOXYPHENYL)-, HYDROCHLOR | ||
| CAS number | 54301-15-4 | molecular formula | C21H19N3O3S·HCl |
| molecular weight | 429.92 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 88.700 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P301+P310: 如误吞咽：立即呼叫急救中心/医生。
WGK Germany：
3
Personal protective equipment：
Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges
RTECS：
PB1081000
UN Number：
2811
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MSDS
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