compound introduction
阿克拉霉素A是一种口服有效的蒽环类抗肿瘤的抗生素 (antibiotic)。阿克拉霉素A是拓扑异构酶 (topoisomerase) I 和 II 的抑制剂。阿克拉霉素A可抑制核酸的合成，特别是 RNA 的合成。阿克拉霉素A可能抑制 26S 蛋白酶复合体以及泛素-ATP 依赖性蛋白水解。 Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis.
