Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。 应用： 奥沙利铂已被用于：通过细胞活力测定，作为结肠直肠腺癌 SW480 细胞中的化学治疗剂；用于通过 MTT 比色法监测肝细胞癌 HepG2 和 HepG2/R 细胞中的细胞存活率；确定对人乳腺癌 MDA-MB-231 细胞的生长抑制作用。 Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin , the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin , and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently. A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula C 8 H 14 N 2 O 4 Pt Empirical formula [Pt((R,R)-dach)(ox)] Molecular weight 397.28 Metal Pt Theoretical metal content 49 Physical state powder Color white
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Oxaliplatin
Dangerous GoodsCAS number：61825-94-3 molecular formula：C8H14N2O4Pt
overview
compound introduction
Specs
| Chinese alias | (反-1,2-环己烷二胺)草酸铂(II) | ||
| English alias | - | ||
| CAS number | 61825-94-3 | molecular formula | C8H14N2O4Pt |
| molecular weight | 397.29 g/mol | Exact mass | 2mM in Water |
| PSA | 76.600 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H351: 怀疑引起遗传缺陷 H317: 可能引起皮肤过敏反应
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P308+P313: 如接触到或有疑虑：求医/就诊。 P202: 在阅读并理解所有安全预防措施之前，不要进行操作。
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS：
TP2275850
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
61825-94-3 | Oxaliplatin, United States Pharmacopeia(USP) Reference Standard.pdf
