Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.Captopril是一种血管紧张素转换酶（ACE）抑制剂，IC50为6 nM。 Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
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Captopril
Dangerous GoodsCAS number：62571-86-2 molecular formula：C9H15NO3S
overview
compound introduction
Specs
| Chinese alias | 卡托普利 | 巯甲丙脯酸 | (S)-1-(3-巯基-2-甲基-1-氧代丙基)-L-脯氨酸 | S)-(-)-1-(3-巯基-2-甲基丙酰基)-L-脯氨酸 | ||
| English alias | Acepress | Captopril [USAN:USP:INN:BAN:JAN] | 1-((2S)-2-Methyl-3-sulfanylpropanoyl)-L-proline # | CHEBI:3380 | DTXSID1037197 | DTXCID9017197 | Tensoprel | Captopril,(S) | Captoprilum [INN-Latin] | Zapto | Tenosbon | 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-p | ||
| CAS number | 62571-86-2 | molecular formula | C9H15NO3S |
| molecular weight | 217.29 g/mol | Exact mass | - |
| PSA | 58.600 Ų | logp | 0.3 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265
WGK Germany：
3
Personal protective equipment：
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS：
UY0550000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
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MSDS
Found 1 shareMSDS
62571-86-2 | Captopril (200 mg).pdf
