Information Divalproex Sodium Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy. Targets HDAC In vitro Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.
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Divalproex Sodium
Dangerous GoodsCAS number：76584-70-8 molecular formula：C16H32NaO4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Depakote | DTXSID70227388 | Natrium hydrogen bis(2-propylvalerat) | Valparin | Valproate semisodique [French] | C76453 | Valproic acid semisodium salt (2:1) | CHEBI:4667 | Depakote (TN) | Valproate semisodium [INN] | Epilex | Valproatum seminatricum (Lati | ||
| CAS number | 76584-70-8 | molecular formula | C16H32NaO4 |
| molecular weight | 311.42 g/mol | Exact mass | ≥99% |
| PSA | 77.400 Ų | logp | - |
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Safety information
pictogram：
GHS08 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H302: 吞食有害 H360: 可能损害生育力或未出生的孩子
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P203:
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MSDS
Found 1 shareMSDS
76584-70-8 | Divalproex Sodium.pdf
