辛伐他汀是药物前体。辛伐他汀是洛伐他汀的半合成衍生物/类似物。辛伐他汀不溶于水，但可溶于极性有机溶剂。 产品用途： 辛伐他汀已用于： • 用于 HMG CoA还原酶(HMGCR)的抑制剂 • 研究其对上皮间质转化(EMT)以及肺腺癌患者预后的影响 • 体内研究检验其对脑肿瘤−启动细胞(BTIC)活力和细胞增殖的影响 • 研究三磷酸腺苷(ATP)-结合盒转运蛋白A7在Jurkat细胞吞噬作用中的作用 • 研究其对小鼠内皮功能障碍和炎症的影响 Product Description Simvastatin is a prodrug. Simvastatin is a semisynthetic derivative/analog of lovastatin. Simvastatin is insoluble in water but is soluble in polar organic solvents. Product Application Simvastatin has been used: • as an inhibitor of HMG CoA reductase (HMGCR) • to study its effects on epithelial to mesenchymal transition (EMT) and the prognosis of patients with lung adenocarcinoma • in in vivo studies to test its effect on brain tumor−initiating cells (BTIC) viability and cell proliferation • to study the role of adenosine triphosphate (ATP)-binding cassette transporter A7 in phagocytosis of Jurkat cells • to study the effect on endothelial dysfunction and inflammation in mice
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Simvastatin
Dangerous GoodsCAS number：79902-63-9 molecular formula：C25H38O5
overview
compound introduction
Specs
| Chinese alias | 舒降脂 | 塞瓦停 | 西伐斯汀 | ||
| English alias | BRN 4768037 | Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester | MK 0733 | SIMVASTATIN [MART.] | Sinvascor | L 644128-000U | Zocord | Sim | ||
| CAS number | 79902-63-9 | molecular formula | C25H38O5 |
| molecular weight | 418.57 g/mol | Exact mass | - |
| PSA | 72.800 Ų | logp | 4.7 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H410: 对水生生物有剧毒并具有长期持续影响 H362: 可能对母乳喂养的孩子造成伤害
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P391: 收集溢出物 P263: 避免在怀孕期间/哺乳期间接触。 P203:
WGK Germany：
2
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
RTECS：
EK7798000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
79902-63-9 | Simvastatin for system suitability.pdf
