Methylprednisolone Aceponate（MPA）

Dangerous Goods

CAS number：86401-95-8 molecular formula：C27H36O7

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders . In Vitro Methylprednisolone aceponate inhibits collagenase promoter activity (in HeLa cells), LPS-induced IL-12p40 secretion (in human PBMCs) and phytohemagglutinin-induced IFN-γ secretion (in human PBMCs) with IC 50 s of 9.3, 16.8, 15.2 nM. Methylprednisolone aceponate induces MMTV promoter and TAT activities with EC 50 s of 21.8 and 20.5 nM respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Methylprednisolone aceponate (topically applied, 50 μL,，Coroton oil-induced Evan blue edema) shows anti-inflammatory effect with an IC 50 of 0.0015%, with low systemic side effect . Methylprednisolone aceponate (0.0001%-0.1%, topically applied) inhibits oedema formation with ED 50 of 0.002% in irritant contact dermatitis in mice and rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Irritant contact dermatitis mice and ratDosage: 0.0001%-0.1% Administration: Topically applied, 10 µL for mice and 20 µL for rats. Result: Significantly inhibited ear inflammation.

Specs

Chinese alias	醋丙酸甲基泼尼松龙 \| 甲基泼尼松龙乙丙酸酯 \| 乙酸-丙酸甲基泼尼松龙 \| 甲泼尼龙丙乙酯
English alias	Aceponate de methylprednisolone [French] \| NCGC00510142-01 \| Advantan \| SH-440 \| ZK 91588 \| SH440 \| SH 440 \| MPA \| [(6s,8r,9r,10s,11s,13s,14s,17r)-17-(2-acetyloxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phe
CAS number	86401-95-8	molecular formula	C27H36O7
molecular weight	472.57 g/mol	Exact mass	-
PSA	107.000 Å²	logp	3.800

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08

Signal word：

Danger

Hazard Statement：

H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。