Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer. In Vitro Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines. Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs). Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Eutopic and ectopic E-MSCs Concentration: 100 nM Incubation Time: 24 h Result: Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines. In Vivo Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Wistar-Furth rats bearing SMtTW tumors Dosage: 0.03-0.6 mg/kg Administration: Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month Result: Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg. Form:Solid
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Quinagolide hydrochloride
CAS number：94424-50-7 molecular formula：C20H34ClN3O3S
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| Chinese alias | 盐酸喹高利特 | ||
| English alias | A844947 | Quinagolide (hydrochloride) | (3S,4aS,10aR)-3-(diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline;hydrochloride | CV205-502 hydrochloride | F85304 | HY-13736A | SDZ-205502 | DTXSID20241478 | D08457 | Quinago | ||
| CAS number | 94424-50-7 | molecular formula | C20H34ClN3O3S |
| molecular weight | 432.02 g/mol | Exact mass | - |
| PSA | 81.300 Ų | logp | - |
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