compound introduction
Perindoprilat是Perindopril的活性代谢产物，它是一种ACE（血管紧张素转化酶）抑制剂，可调节低密度脂蛋白受体相关蛋白（LRP）的活性。LRP是一种多功能的内吞受体，在蛋白酶的更新和细胞外基质蛋白的降解中起作用。众所周知，Perindoprilat抑制血管紧张素I向血管紧张素II的转化，从而降低小动脉压力并增加静脉容量。 Perindoprilat is an active metabolite of Perindopril , an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.
