Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies sμggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。 Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3. Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice
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Orlistat
Dangerous GoodsCAS number：96829-58-2 molecular formula：C29H53NO5
overview
compound introduction
Specs
| Chinese alias | 奧利司他 | (-)-四氢脂抑素 | ||
| English alias | CCG-100851 | DTXCID40820067 | ORLISTAT [MART.] | Orlistat, United States Pharmacopeia (USP) Reference Standard | Q424163 | [(2S)-1-[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2R)-2-formamido-4-methylpentanoate | BDBM24567 | HSDB 7556 | L-Leucine, N- | ||
| CAS number | 96829-58-2 | molecular formula | C29H53NO5 |
| molecular weight | 495.75 g/mol | Exact mass | - |
| PSA | 81.700 Ų | logp | 10.000 |
numbering system
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physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09
Hazard Statement：
H411: 对水生生物有毒并具有长期持续影响 H412: 对水生生物有害并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
WGK Germany：
3
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
RTECS：
OH3167600
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MSDS
Found 1 shareMSDS
96829-58-2 | Orlistat (200 mg) (COLD SHIPMENTREQUIRED).pdf
