Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments sμggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro.Desloratadine是人H1受体拮抗剂。 Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro. It is a potent antagonist for human histamine H1 receptor used to treat allergies.
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Desloratadine
Dangerous GoodsCAS number：100643-71-8 molecular formula：C19H19ClN2
overview
compound introduction
Specs
| Chinese alias | 地氯雷他定 | ||
| English alias | DESLORATADINE [USP MONOGRAPH] | LORATADINE IMPURITY D (EP IMPURITY) | Pharmakon1600-01505393 | Aerius | LORATADINE IMPURITY D [EP IMPURITY] | BBL010777 | Opulis | Sch34117 | Sch-34117 | AKOS000280921 | BDBM50073179 | Clarinex (TN) | DESLORATADINE (USP MON | ||
| CAS number | 100643-71-8 | molecular formula | C19H19ClN2 |
| molecular weight | 310.83 g/mol | Exact mass | - |
| PSA | 24.900 Ų | logp | 4.5 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H411: 对水生生物有毒并具有长期持续影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P36
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
100643-71-8 | Desloratadine, United States Pharmacopeia(USP) Reference Standard.pdf
