帕米膦酸二钠盐是一种双膦酸盐钙代谢调节剂，可特异性诱导骨骼中钙的重吸收。此外，帕米膦酸选择性激活外周血单核细胞中的γδT细胞。替代研究表明，帕米膦酸二钠盐可促进成骨细胞增殖和分化，同时抑制破骨细胞生成和破骨细胞功能。此外，帕米膦酸通过抑制PC-3细胞中的uPA mRNA来下调尿激酶型纤溶酶原激活剂的表达。帕米膦酸二钠盐是FDPS（法呢基二磷酸合酶）的抑制剂。 Pamidronate, Disodium Salt is a bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. In addition, Pamidronate selectively activates γδTcells in peripheral blood mononuclear cells. Alternate studies indicate that Pamidronate, Disodium Salt promotes osteoblast proliferation and differentiation while inhibiting osteoclastogenesis and osteoclast function. Furthermore, Pamidronate down-regulates urokinase-type plasminogen activator expression by suppressing uPA mRNA in PC-3 cells. Pamidronate, Disodium Salt is an inhibitor of FDPS (farnesyl diphosphate synthase).
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Pamidronate, Disodium Salt
Dangerous GoodsCAS number：109552-15-0 molecular formula：C3H19NNa2O12P2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Z2216208641 | DTXSID101016128 | Aredia (TN) | F12796 | sodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogen phosphonate) pentahydrate | D00941 | KS-1092 | Pamidronate sodium pentahydrate | Disodium pamidronate pentahydrate | sodium 3-amino-1-hydroxyprop | ||
| CAS number | 109552-15-0 | molecular formula | C3H19NNa2O12P2 |
| molecular weight | 369.11 g/mol | Exact mass | ≥95% |
| PSA | 172.000 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08 , GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H371: 可能会损坏器官
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良
RTECS：
SZ6522666
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
109552-15-0 | Pamidronate disodium.pdf
