compound introduction
替卡普里拉特 替莫卡普利的降压和活性代谢产物。该化合物抑制ACE（血管紧张素转换酶），该酶通过从C末端切割二肽来催化血管紧张素I向血管紧张素II的转化。血管紧张素II与血管紧张素II受体结合，引起血管收缩和血压升高。此外，血管紧张素II的结合会导致醛固酮的释放，从而导致远端小管中水和钠的重吸收。 Temocaprilat is an antihypertensive and the active metabolite of temocapril. This compound inhibits ACE (angiotensin-converting enzyme), which catalyzes the conversion of angiotensin I to angiotensin II by cleaving a dipeptide from the C-terminus. Angiotensin II binds to angiotensin II receptors, causing vasoconstriction and an increase in bloodpressure. Furthermore, the binding of angiotensin II causes the release of aldosterone, which causes reabsorption of water and sodium in the distal tubule.
