Temoporfin

Dangerous Goods

CAS number：122341-38-2 molecular formula：C44H32N4O4

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers . In Vitro A detailed confocal fluorescence microscopy study of a human adenocarcinoma shows weak localization of Temoporfin in lysosomes and mitochondria. Instead, it is found to be localized in the endoplasmic reticulum (ER) and the Golgi apparatus. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Temoporfin in liver tissue decreases rapidly in time after initial high levels at 4 h after administration (0.1-0.3 mg/kg). In tumour tissue no decrease in photosensitizer levels occurred, with Temoporfin remaining high up to 48 h after administration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Specs

Chinese alias	替莫泊芬
English alias	3-[10,15,20-tris(3-hydroxyphenyl)-2,3,22,24-tetrahydroporphyrin-5-yl]phenol \| A50001 \| NCGC00183280-01 \| TEMOPORFIN [EMA EPAR] \| AS-73700 \| meso-Tetrahydroxyphenylchlorin \| Meso-tetra-(hydroxyphenyl)chlorin \| TEMOPORFIN [USAN] \| 3,3',3'',3'''-(7,8-Dihydro
CAS number	122341-38-2	molecular formula	C44H32N4O4
molecular weight	680.75 g/mol	Exact mass	≥97%
PSA	138.000 Å²	logp	8.800

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H317: 可能引起皮肤过敏反应

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。