Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma. In Vitro Tipelukast inhibits the binding of [ 3 H] LTD4 to the LTD4 receptors on pul-monary cell membrane of guinea-pigs (IC 50 = 2.3 μmol). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction . Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:LTD 4 6.41 (pA2, In guinea-pigs) LTE 4 6.45 (pA2, In guinea-pigs)
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Tipelukast
CAS number：125961-82-2 molecular formula：C29H38O7S
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| Chinese alias | 替鲁司特 | ||
| English alias | 4-(6-Acetyl-3-(3-((4-acetyl-3-hydroxy-2-propylphenyl)thio)propoxy)-2-propylphenoxy)butanoic acid | TIPELUKAST [INN] | TIPELUKAST [USAN] | 4-(6-Acetyl-3-(3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy)-2-propylphenoxy)butyric acid | D06659 | Butanoic aci | ||
| CAS number | 125961-82-2 | molecular formula | C29H38O7S |
| molecular weight | 530.67 g/mol | Exact mass | ≥99% |
| PSA | 135.000 Ų | logp | 6.500 |
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