Aripiprazole是一种人5-HT1A受体激动剂，Ki为4.2 nM。 阿立哌唑的主要成分为 3, 4 二氢-2-(1H) 喹啉酮。 阿立哌唑已被用于研究其对乳腺肿瘤发生的影响，通过逆转录病毒传递受体酪氨酸蛋白激酶 2 或 HRas 原癌基因、gtp 酶或通过转基因表达 Wnt-1（原癌蛋白）介导。也用于研究其对幼年自发性高血压大鼠的行为和神经化学作用。 阿立哌唑已被用于研究阿立哌唑对注意缺陷多动障碍 (ADHD) 模型幼年自发性高血压大鼠 (SHR) 的行为和神经化学的影响。 A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity. Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity. Aripiprazole has been used to study behavioral and neurochemical effects of aripiprazole treatment in juvenile spontaneously hypertensive rats (SHR), a model for attention deficit hyperactivity disorder (ADHD). Aripiprazole has been used to study its effect on mammary tumorigenesis, mediated by retrovirus delivery of receptor tyrosine-protein kinase 2 or HRas proto-oncogene, GTPase or by transgenic expression of Wnt-1 (proto-oncoprotein). It has also been used to study its behavioral and neurochemical effects in juvenile spontaneously hypertensive rats.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Aripiprazole
Dangerous GoodsCAS number：129722-12-9 molecular formula：C23H27Cl2N3O2
overview
compound introduction
Specs
| Chinese alias | 阿立哌唑 | 7-[4-[4-(2, 3-二氯苯基)-1-哌嗪基]丁氧基]-3, 4-二氢-2(1H)-喹啉酮 | 7-[4-[4-(2,3-二氯苯基)-1-哌嗪基] 丁氧基]-3,4-二氢-2 (1H)-喹啉酮 | 7-{4-[4-(2,3-二氯苯基)-L-哌嗪基]丁氧基}-3,4-二氢-2(1H)-喹啉酮 | ||
| English alias | 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril | Aripiprazole [USAN:INN:BAN] | Aripiprazole- Bio-X | HMS3373D04 | Asprito | BCP04902 | OPC-14597 | s1975 | Aripiprex | Pripiprazole | Abilify Maintena Kit | Abilify MyCite | ||
| CAS number | 129722-12-9 | molecular formula | C23H27Cl2N3O2 |
| molecular weight | 448.39 g/mol | Exact mass | - |
| PSA | 44.800 Ų | logp | 4.6 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒 H302: 吞食有害
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
RTECS：
VC8275950
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
129722-12-9 | Aripiprazole, United States Pharmacopeia(USP) Reference Standard.pdf
