compound introduction
2-丁基-3-（3,5-二碘-4-羟基苯甲酰基）苯并呋喃是抗心律不齐化合物胺碘酮的类似物。2-丁基-3-（3,5-二碘-4-羟基苯甲酰基）苯并呋喃由母体化合物的O-脱烷基化产生。胺碘酮的类似物，包括2-丁基-3-（3,5-二碘-4-羟基苯甲酰基）苯并呋喃被证明具有竞争性抑制5'-T4（甲状腺素）去碘的作用。 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran is an analog of the anti-arrhythmic compound Amiodarone . 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran results from O-dealkylation of the parent compound. Analogs of Amiodarone including 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran were demonstrated to competitively inhibit 5′-T4 (thyroxine) deiodination.
