CAS number：146426-40-6 molecular formula：C21H20ClNO5
Flavopiridol能与ATP竞争抑制CDK，对CDK1，CDK2，CDK4和CDK6的IC50为40 nM，同时对EGFR和PKA也有一定抑制性。A synthetic flavonoid derivative, potent inhibitor of CDKs. Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA A synthetic flavonoid derivative, potent inhibitor of CDKs.
| Chinese alias | 夫拉平度 | ||
| English alias | L868275 | ALVOCIDIB [MART.] | AS-74761 | Q4063441 | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one | 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)- | ||
| CAS number | 146426-40-6 | molecular formula | C21H20ClNO5 |
| molecular weight | 401.85 g/mol | Exact mass | - |
| PSA | 90.200 Ų | logp | 3.3 |
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