Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. A competitive inhibitor of HMG-CoA reductase
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Pitavastatin Calcium
Dangerous GoodsCAS number：147526-32-7 molecular formula：C50H46CaF2N2O8
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compound introduction
Specs
| Chinese alias | 匹伐他汀钙 | 匹伐他汀钙 | ||
| English alias | (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt | Itavastatin calcium | NK 104 | Q-201590 | PITAVASTATIN CALCIUM [ORANGE BOOK] | calcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoli | ||
| CAS number | 147526-32-7 | molecular formula | C50H46CaF2N2O8 |
| molecular weight | 880.98 g/mol | Exact mass | 10mM in DMSO |
| PSA | 187.000 Ų | logp | - |
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physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H361f: 怀疑破坏生育力
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P201: 使用前获取特殊说明 P308+P313: 如接触到或有疑虑：求医/就诊。 P202: 在阅读并理解所有安全预防措施之前，不要进行操作。
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