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Roflumilast

Dangerous Goods

CAS number:162401-32-3    molecular formula:C17H14Cl2F2N2O3

overview

compound introduction

Roflumilast is a selective phosphodiesterase 4 (PDE4) (IC50 = 0.8 nM) inhibitor. Inhibition of PDE4 prevents the hydrolysis of phosphodiesters, which play a key role in signal transduction. This compound has anti-inflammatory properties and is particularly effective at reducing inflammation in lung tissue.A selective inhibitor of phosphodiesterase 4 Roflumilast is a selective phosphodiesterase 4 (PDE4) (IC50 = 0.8 nM) inhibitor. Inhibition of PDE4 prevents the hydrolysis of phosphodiesters, which play a key role in signal transduction. This compound has anti-inflammatory properties and is particularly effective at reducing inflammation in lung tissue. A selective inhibitor of phosphodiesterase 4

Specs

Chinese alias罗氟司特
English aliasDTXSID8044123 | ROFLUMILAST [JAN] | BYK 20869 | BYK20869 | BYK-20869 | MLS006010074 | Roflumilast (Daxas) | ROFLUMILAST (MART.) | 0P6C6ZOP5U | ROF | SY008710 | PB29130 | UNII-0P6C6ZOP5U | ZORYVE | 1xmu | 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)
CAS number162401-32-3molecular formulaC17H14Cl2F2N2O3
molecular weight403.21 g/molExact mass-
PSA60.500 Ųlogp4.6

numbering system

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physicochemical properties

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Safety information

pictogram:
GHS07
Signal word:
Warning
Hazard Statement:
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移
WGK Germany:
3

Production methods and uses

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upstream information

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downstream information

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MSDS

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