Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.A cholesterol transport inhibitor that binds to NPC1L1 Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels. A cholesterol transport inhibitor that binds to NPC1L1
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Ezetimibe
Dangerous GoodsCAS number：163222-33-1 molecular formula：C24H21F2NO3
overview
compound introduction
Specs
| Chinese alias | 依泽替米贝 | (3R,4S)-1-(4-氟苯基)-3-[(S)-3-(4-氟苯基)-3-羟基丙基]-4-(4-羟基苯基)-2-氮杂环丁酮 | 依折麦布 | ||
| English alias | Zetia | Ezetrol | F0112 | NC00134 | Q18472686 | MLS000759443 | (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one | Ezetimibe (JAN/USP/INN) | EZETIMIBE (USP MONOGRAPH) | CCG-100884 | EOR26LQQ24 | EZETIM | ||
| CAS number | 163222-33-1 | molecular formula | C24H21F2NO3 |
| molecular weight | 409.43 g/mol | Exact mass | - |
| PSA | 60.800 Ų | logp | 4 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS09
Signal word：
Warning
Hazard Statement：
H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
163222-33-1 | EZETIMIBE, UNITED STATES PHARMACOPEIA(USP) REFERENCE STANDARD.pdf
