Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM. 添加用途： Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line. Product Description Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM. Product Application Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.
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Erlotinib HCl (OSI-744)
Dangerous GoodsCAS number：183319-69-9 molecular formula：C22H23N3O4·HCl
overview
compound introduction
Specs
| Chinese alias | 盐酸埃罗替尼 | 774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐 | 盐酸厄洛替尼 | 埃罗替尼 盐酸盐 | ||
| English alias | HCl, Erlotinib | KS-1202 | CP-358,774-01 | ERLOTINIB HYDROCHLORIDE [MI] | N-(3-ETHENYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE | Tarceva (Erlotinib Hydrochloride) | GTTBEUCJPZQMDZ-UHFFFAOYSA-N | CHEBI:53509 | ERLOTINIB HYDROCHLORID | ||
| CAS number | 183319-69-9 | molecular formula | C22H23N3O4·HCl |
| molecular weight | 429.9 g/mol | Exact mass | ≥99% |
| PSA | 74.700 Ų | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS09 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H351: 怀疑引起遗传缺陷 H373: 通过长时间或反复暴露对器官造成损害 H411: 对水生生物有毒并具有长期持续影响 H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H317: 可能引起皮肤过敏反应 H332: 吸入有害 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子 H302+H332
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
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