compound introduction
Derquantel是一种半合成的对乙酰氨基甲酰胺类似物，它是通过N-保护，还原，N-去保护和最终还原的四个步骤除去2-氧代基而制得的。Derquantel是一种有效的杀线虫剂，是第一个与阿维菌素联合成功商业化的对乙酰氨基甲酰胺。与其他副鞘氨酰胺一样，Derquantel在线虫中诱发松弛性麻痹，认为这是由于抑制了作为乙酰胆碱拮抗剂的AChR（烟碱乙酰胆碱受体）所致。 Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of AChR (nicotinic acetylcholine receptors) acting as an antagonist of acetylcholine.
