CAS number：202409-33-4 molecular formula：C18H15ClN2O2S
Etoricoxib(MK-0663)能选择性抑制COX-2，IC50为1.1_mu_M（LPS诱导的前列腺素E2合成实验），而对COX-1的IC50则为116_mu_M（凝血后血清血栓素B2生成实验）。A specific inhibitor of COX-2. EtoricoxibEtoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood). A specific inhibitor of COX-2.
| Chinese alias | 依托考昔 | 5-氯-6'-甲基-3-[4-(甲磺酰基)苯基]]-2,3'-联吡啶 | 5-氯-3-[4-(甲磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶 | ||
| English alias | MK-663 | MK-0663 | Etoricoxibe | F2173-0490 | SR-05000001486 | HY-15321 | Kingcox | 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine | HCC 150 | Nucoxia | CHLOROACETALDEHYDE [MI] | J-013140 | 2,3-Dihydroxybenzoate, IV | 5-Chloro-3-(4 | ||
| CAS number | 202409-33-4 | molecular formula | C18H15ClN2O2S |
| molecular weight | 358.84 g/mol | Exact mass | - |
| PSA | 68.300 Ų | logp | 3.3 |
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