compound introduction
Neflamapimod (VX-745) 是有效的，可穿过血脑屏障的，高选择性的 p38α 抑制剂，对 p38α 的 IC50 值为 10 nM，p38β 的 IC50 值为 220 nM。Neflamapimod (VX-745) 具有抗炎活性。
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VX-745
CAS number：209410-46-8 molecular formula：C19H9Cl2F2N3OS
overview
Specs
| Chinese alias | - | ||
| English alias | BCPP000015 | s1458 | BRD-K91900765-001-01-9 | Kinome_3767 | 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one | 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one | 5T-0205 | CCG-269082 | AC | ||
| CAS number | 209410-46-8 | molecular formula | C19H9Cl2F2N3OS |
| molecular weight | 436.27 g/mol | Exact mass | - |
| PSA | 70.300 Ų | logp | 5.1 |
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