compound introduction
米卡芬净是属于棘球菌素类的半合成环状脂肽。与该级别的其他市售半合成衍生物不同，米卡芬净不是从棘皮菌素衍生而来，而是从FR901379衍生而来，后者含有酚硫酸盐以增强水溶性，这是该类别中的一个严重限制。米卡芬净的抗真菌特性源于其抑制β-（1,3）-D-葡聚糖合成的能力，β-（1,3）-D-葡聚糖是易感真菌细胞壁的重要组成部分。 Micafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class. Unlike other marketed semi-synthetic derivatives in this class, micafungin is not derived from echinocandin but rather from FR901379, which contains a phenolic sulphate to enhance aqueous solubility, a serious limitation in the class. Micafungin's antifungal properties stem from its ability to inhibit the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall in susceptible fungi.
