Sorafenib

Dangerous Goods

CAS number：284461-73-0 molecular formula：C21H16ClF3N4O3

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Sorafenib是Raf-1, B-Raf和VEGFR-2的多重激酶抑制剂，IC50分别为6 nM, 22 nM和90 nM。还能抑制野生型和V599E突变型BRAF活性。 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway

Specs

Chinese alias	-
English alias	4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide \| SCHEMBL8218 \| L01XE05 \| NSC7177 \| UNII-9ZOQ3TZI87 \| NSC747971 \| NSC-747971 \| BAY 439006 \| BAY 43-9006 \| 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]ca
CAS number	284461-73-0	molecular formula	C21H16ClF3N4O3
molecular weight	464.83 g/mol	Exact mass	-
PSA	92.400 Å²	logp	4.100

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS09

Signal word：

Danger

Hazard Statement：

H351: 怀疑引起遗传缺陷 H402: 对水生生物有害 H410: 对水生生物有剧毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害

Statement of Preventive Measures：

P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P263: 避免在怀孕期间/哺乳期间接触。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。