compound introduction
Dasatinib是一种Src/Abl抑制剂，对生型Abl和Src激酶均有抑制作用，IC50分别为0.6 nM和0.8 nM。Directly targets wild-type and mutant c-Abl kinase domains Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of
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Dasatinib
Dangerous GoodsCAS number：302962-49-8 molecular formula：C22H26ClN7O2S
overview
Specs
| Chinese alias | 达沙替尼 | ||
| English alias | BMS 354825 | AR-270/43507994 | Dasatinib (JAN/INN) | HMS3744C11 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | SB17284 | Dasatinib - BMS-354825 | DTXSID50235486 | Pharmakon | ||
| CAS number | 302962-49-8 | molecular formula | C22H26ClN7O2S |
| molecular weight | 488.01 g/mol | Exact mass | - |
| PSA | 135.000 Ų | logp | 3.6 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06 , GHS08 , GHS09 , GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H301: 吞咽会中毒 H351: 怀疑引起遗传缺陷 H318: 造成严重的眼睛损伤 H410: 对水生生物有剧毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P391: 收集溢出物 P330: 漱口 P203: 使用
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