compound introduction
GW 501516 (GW 1516) 是 PPARδ 的激动剂，EC50 值为 1.1 nM。 GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model. GW501516 has been used as a peroxisome proliferator-activated receptor (PPAR) δ agonist: to treat the differentiated L6 myotubes to test its effect on free fatty acid (FFA) uptake under mild hypoxia conditions in organoid culture medium to test its effect on self-renewal of PR domain containing 16 (Prdm16)-depleted intestinal stem cells as a component in the defatting medium for primary human hepatocytes (PHH) culture
