Cinacalcet HCl

Dangerous Goods

CAS number：364782-34-3 molecular formula：C22H22F3N·HCl

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies sμggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.An allosteric activator of CaSR Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile. An allosteric activator of CaSR

Specs

Chinese alias	盐酸西那卡塞 \| 盐酸甲状旁腺激素 \| N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐
English alias	1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride \| CAS-364782-34-3 \| CINACALCET HYDROCHLORIDE [USP-RS] \| MLS006010213 \| Z1198150431 \| DTXSID3046792 \| NPS-1493 \| CNC-HCl \| N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(t
CAS number	364782-34-3	molecular formula	C22H22F3N·HCl
molecular weight	393.87 g/mol	Exact mass	≥99%
PSA	12.000 Å²	logp	-

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS08 , GHS09 , GHS05 , GHS07

Signal word：

Danger

Hazard Statement：

H319: 引起严重眼睛刺激 H373: 通过长时间或反复暴露对器官造成损害 H412: 对水生生物有害并具有长期持续影响 H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H312: 皮肤接触有害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本