CAS number：366017-09-6 molecular formula：C25H23F3N4O2
Mubritinib (TAK 165)是一种有效的HER2/ErbB2抑制剂，IC50为6 nM；对EGFR， FGFR， PDGFR， JAK1， Src和Blk没有抑制活性。A selective, potent, and irreversible ErbB2 and EGFR inhibitor. Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk. A selective, potent, and irreversible ErbB2 and EGFR inhibitor.
| Chinese alias | 木利替尼 | ||
| English alias | TAK165 | DNDI1268116 | M3058 | SCHEMBL50451 | CCG-269433 | Mubritinib (USAN/INN) | D04025 | DTXSID501026014 | [4-[4-[[2-[(E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-1,2,3-triazole | 1-[4-[4-[[2-[(E)-2-[4-(Trifluorome | ||
| CAS number | 366017-09-6 | molecular formula | C25H23F3N4O2 |
| molecular weight | 468.47 g/mol | Exact mass | - |
| PSA | 66.000 Ų | logp | 5.4 |
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