CAS number：387867-13-2 molecular formula：C31H42N6O4
Tandutinib (MLN518)是一种有效的FLT3拮抗剂，IC50为0.22 μM，同时也抑制PDGFR和c-Kit，对FLT3作用效果比CSF-1R强15到20倍，比FGFR， EGFR和KDR等强100倍以上A piperazinyl quinazoline receptor tyrosine kinase inhibitor Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. A piperazinyl quinazoline receptor tyrosine kinase inhibitor
| Chinese alias | 坦度替尼 | ||
| English alias | Pharmakon1600-01502277 | DTXCID5028873 | NCGC00241097-07 | SMR004702776 | UNII-E1IO3ICJ9A | 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide | AMY32698 | HMS3654O09 | N-(4-isopropoxyphenyl)-4-(6- | ||
| CAS number | 387867-13-2 | molecular formula | C31H42N6O4 |
| molecular weight | 562.72 g/mol | Exact mass | - |
| PSA | 92.300 Ų | logp | 4.6 |
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