compound introduction
Macitentan是一种口服有效的，非肽类，ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。 Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.
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Macitentan
Dangerous GoodsCAS number：441798-33-0 molecular formula：C19H20Br2N6O4S
overview
Specs
| Chinese alias | 马西替坦 | ||
| English alias | EX-A544 | MACITENTAN [WHO-DD] | Opsumit (TN) | N-(5-(4-BROMOPHENYL)-6-(2-((5-BROMOPYRIMIDIN-2-YL)OXI)ETHOXY)PYRIMIDIN-4-YL)-N'-PROPYLSULFURIC DIAMIDE | n-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-n'-propylaminosulfonamide | | ||
| CAS number | 441798-33-0 | molecular formula | C19H20Br2N6O4S |
| molecular weight | 588.27 g/mol | Exact mass | - |
| PSA | 137.000 Ų | logp | 3.7 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS08
Signal word：
Danger
Hazard Statement：
H360: 可能损害生育力或未出生的孩子
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。
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MSDS
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