CAS number：453562-69-1 molecular formula：C22H23N5O
Motesanib (AMG-706)是ATP竞争性VEGFR1，2，3抑制剂，IC50分别为 2 nM，3 nM和6 nM，对c-Kit的IC50为8 nM。An inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit. Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. An inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.
| Chinese alias | 莫特塞尼 | ||
| English alias | N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide | NSC800801 | NSC-800801 | HMS3244B09 | HY-10228 | N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide | SCHEMBL2416976 | D | ||
| CAS number | 453562-69-1 | molecular formula | C22H23N5O |
| molecular weight | 373.46 g/mol | Exact mass | - |
| PSA | 78.900 Ų | logp | 3.9 |
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