Aleglitazar (R1439;RO0728804) 是一种高效的 PPARα/γ 双重激动剂,对人 PPARα 和 PPARγ 作用的 IC50 分别为 38 nM 和 19 nM。Aleglitazar 可用于 II 型糖尿病的研究。 Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes。
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Aleglitazar
CAS number:475479-34-6 molecular formula:C24H23NO5S
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| Chinese alias | 阿格列扎 | ||
| English alias | DB08915 | RO7 | SMR000024554 | BDBM50277897 | DTXSID70197193 | R 1439 | BENZO(B)THIOPHENE-7-PROPANOIC ACID, .ALPHA.-METHOXY-4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)-, (.ALPHA.S)- | D08845 | (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethox | ||
| CAS number | 475479-34-6 | molecular formula | C24H23NO5S |
| molecular weight | 437.51 g/mol | Exact mass | - |
| PSA | 110.000 Ų | logp | 5.1 |
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