Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity. In Vitro Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC 50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Rosabulin
CAS number：501948-05-6(DMSO) molecular formula：C22H16N4O2S
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| Chinese alias | 罗莎布林 | ||
| English alias | - | ||
| CAS number | 501948-05-6(DMSO) | molecular formula | C22H16N4O2S |
| molecular weight | 400.45 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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