用途 SPhos可用作以下反应的配体： 钯催化的Boc-保护氨甲基三氟硼酸盐与芳基氯化物或杂芳基氯化物之间的Suzuki-Miyaura交叉偶联反应，形成相应的氨甲基芳烃。 钯催化的4-甲基取代哌啶基锌试剂与不同芳基或杂芳基碘化物之间的Suzuki-Miyaura交叉偶联反应，形成各种取代哌啶。 riccardin C多步合成过程中的分子内Suzuki-Miyaura偶联，形成18-元大环。 与钯一起使用，产生用于C-N键形成的高活性催化剂。 用于 Suzuki-Miyaura 偶联反应的高通用配体；芳基氯、位阻二芳基、杂二芳基化合物。 Application SPhos may be used as a ligand in the following processes: Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes. Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines. Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C. Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation. Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
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2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl
Dangerous GoodsCAS number：657408-07-6 molecular formula：C26H35O2P
overview
compound introduction
Specs
| Chinese alias | 2-二环己基膦基-2',6'-二甲氧基联苯基 | 二环己基(2',6'-二甲氧基-[1,1'-联苯基]-2-基)膦 | ||
| English alias | S Phos | SPhos | dicyclohexyl({2',6'-dimethoxy-[1,1'-biphenyl]-2-yl})phosphane | dicyclohexylphosphino-2',6'-dimethoxybiphenyl | XI1MQ32186 | SY011025 | dicyclohexyl-(6',2'-dimethoxybiphenyl-2-yl)phosphine | 2-(dicyclohexylphosphino)-2',6'-dimethoxy-1,1'- | ||
| CAS number | 657408-07-6 | molecular formula | C26H35O2P |
| molecular weight | 410.53 g/mol | Exact mass | ≥98% |
| PSA | 18.500 Ų | logp | 6.700 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H317: 可能引起皮肤过敏反应 H312: 皮肤接触有害 H332: 吸入有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
WGK Germany：
3
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
657408-07-6 | SPhos.pdf
