CAS number：698387-09-6 molecular formula：C30H29ClN6O3
Neratinib (HKI-272)是一种高度选择性的HER2和EGFR抑制剂，IC50分别为59 nM和92 nM；微弱抑制KDR和Src，对Akt，CDK1/2/4， IKK-2， MK-2， PDK1， c-Raf和c-Met没有显著的抑制作用。Phase 3。 Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3. A potent and selective inhibitor of EGFR and HER2
| Chinese alias | 来那替尼 | 来那替尼 (HKI-272) | ||
| English alias | EC 244-343-6 | N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | CHEBI:61397 | N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | | ||
| CAS number | 698387-09-6 | molecular formula | C30H29ClN6O3 |
| molecular weight | 557.04 g/mol | Exact mass | - |
| PSA | 112.000 Ų | logp | 4.9 |
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